The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

被引：21

作者：

Formicola, Beatrice ^{[1
]}

Dal Magro, Roberta ^{[1
]}

Montefusco-Pereira, Carlos, V ^{[2
]}

Lehr, Claus-Michael ^{[2
]}

Koch, Marcus ^{[3
]}

Russo, Laura ^{[4
]}

Grasso, Gianvito ^{[5
]}

Deriu, Marco A. ^{[6
]}

Danani, Andrea ^{[5
]}

Bourdoulous, Sandrine ^{[7
]}

Re, Francesca ^{[1
]}

机构：

[1] Univ Milano Bicocca, Sch Med & Surg, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy

[2] Saarland Univ, Helmholtz Inst Pharmaceut Res Saarland, Dept Drug Delivery, D-66123 Saarbrucken, Germany

[3] Leibniz Inst New Mat, Campus D22, D-66123 Saarbrucken, Germany

[4] Univ Milano Bicocca, Dept Biotechnol & Biosci, Bio Organ Chem Lab, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy

[5] USI, SUPSI, IDSIA, Manno, Switzerland

[6] Politecn Torino, Dept Mech & Aerosp Engn DIMEAS, Corso Duca Abruzzi 24, I-10128 Turin, Italy

[7] INSERM, Inst Cochin, U1016, Paris, France

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2019年 / 17卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

Nanoparticles; Liposomes; Brain; Blood-brain barrier; Drug delivery; Doxorubicin; Chlorotoxin; Glioblastoma; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; ANNEXIN A2; PEPTIDE; TRANSPORT; THERAPY; MODEL;

D O I：

10.1186/s12951-019-0546-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

引用

页数：7

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