Pharmacological DNA demethylation: Implications for cancer immunotherapy

被引：23
|
作者：
Roulois, David [1 ]
Yau, Helen Loo [1 ,2 ]
De Carvalho, Daniel D. [1 ,2 ]
机构：
[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
5-AZA-CdR; colorectal cancer; DNA methylation; decitabine; epigenetic therapy; CELLS;
D O I：
10.1080/2162402X.2015.1090077
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent studies have demonstrated that DNA demethylation agents can mimic a viral infection by induction of dsRNAs. This viral mimicry leads to an antiviral response mediated by the cytosolic pattern recognition receptor MDA5, followed by MAVS (IPS1) activation, IRF7 nuclear translocation and upregulation of type III Interferon and interferon-stimulated genes.
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页数：3
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