Testicular Hypofunction and Multiple Sclerosis Risk: A Record-Linkage Study

被引：35
|
作者：
Pakpoor, Julia [1 ]
Goldacre, Raph [2 ]
Schmierer, Klaus [3 ,4 ]
Giovannoni, Gavin [3 ,4 ]
Goldacre, Michael J. [2 ]
机构：
[1] Univ Oxford, Sch Med, John Radcliffe Hosp, Oxford OX3 7LF, England
[2] Univ Oxford, Nuffield Dept Populat Hlth, Unit Hlth Care Epidemiol, Oxford OX3 7LF, England
[3] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London, England
[4] Royal London Hosp, Dept Neurol, Barts Hlth Natl Hlth Serv Trust, London E1 1BB, England
来源：
ANNALS OF NEUROLOGY | 2014年 / 76卷 / 04期
关键词：
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TESTOSTERONE; AXIS;
D O I：
10.1002/ana.24250
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The influence of gonadal hormones on multiple sclerosis (MS) is not well characterized and has thus far been investigated primarily in animal models or as a proposed therapeutic approach. We investigated a potential association between testicular hypofunction, as a proxy for low testosterone levels, and MS risk through analysis of linked English national Hospital Episode Statistics from 1999 to 2011. We report a strong positive association between testicular hypofunction and subsequent MS (rate ratio = 4.62, 95% confidence interval 5 2.3-8.24, p < 0.0001). Future work should aim more directly to elucidate the relationship between testosterone levels and MS in both males and females.
引用
收藏
页码：625 / 628
页数：4
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