Epigenetic changes in Mycobacterium tuberculosis and its host provide potential targets or biomarkers for drug discovery and clinical diagnosis

被引：12
|
作者：
Sui, Jing [1 ,2 ]
Qiao, Wenliang [3 ]
Xiang, Xinrong [1 ,2 ]
Luo, Youfu [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
[3] Sichuan Univ, Lung Canc Ctr, Lab Lung Canc, Western China Hosp, Chengdu, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2022年 / 179卷
基金：
中国国家自然科学基金;
关键词：
Mycobacterium tuberculosis; Epigenetics; DNA methylation; Histone modification; MicroRNA; METALLOPROTEINASE-1; AND-3; EXPRESSION; RIBOSOMAL-RNA METHYLTRANSFERASE; NF-KAPPA-B; DNA METHYLATION; IMMUNE-RESPONSES; CPG DNA; MATRIX METALLOPROTEINASES; DIRECTED THERAPY; INNATE IMMUNITY; VITAMIN-D;
D O I：
10.1016/j.phrs.2022.106195
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tuberculosis infection caused by the contagious pathogen Mycobacterium tuberculosis (MTB) is one of the ancient diseases in the world. The problem of drug resistance is a difficulty in tuberculosis treatment. MTB engendered epigenetic changes play vital parts in escaping the host immune response and bring about the persistence as well as bacterial expansion. This article describes the epigenetic changes that occur in the pathogen MTB and its host during infection, including DNA methylation, histone modification and microRNA, and summarizes their research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat against drug-resistant tuberculosis.
引用
收藏
页数：13
相关论文
共 50 条
  • [41] Comprehensive, comparative exploration of the Mycobacterium tuberculosis proteome to identify novel vaccine targets, drug targets and disease-associated biomarkers
    Blackburn, J.
    FEBS JOURNAL, 2013, 280 : 475 - 475
  • [42] Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets
    Briken, Volker
    CURRENT DRUG TARGETS, 2008, 9 (02) : 150 - 157
  • [43] STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection
    Yi, Xing-Hao
    Zhang, Bo
    Fu, Yu-rong
    Yi, Zheng-jun
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (05) : 2866 - 2878
  • [44] Bioinformatics Analysis to Uncover the Potential Drug Targets Responsible for Mycobacterium tuberculosis Peptidoglycan and Lysine Biosynthesis
    Pitaloka, Dian Ayu Eka
    Izzati, Afifah
    Amirah, Siti Rafa
    Syakuran, Luqman Abdan
    Irham, Lalu Muhammad
    Putri, Athika Darumas
    Adikusuma, Wirawan
    BIOINFORMATICS AND BIOLOGY INSIGHTS, 2023, 17
  • [45] Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis
    Tao Cui
    Lei Zhang
    Xizhou Wang
    Zheng-Guo He
    BMC Genomics, 10
  • [46] Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis
    Cui, Tao
    Zhang, Lei
    Wang, Xizhou
    He, Zheng-Guo
    BMC GENOMICS, 2009, 10
  • [47] In silico discovery of potential drug molecules to improve the treatment of isoniazid-resistant Mycobacterium tuberculosis
    Jagadeb, Manaswini
    Rath, Surya Narayan
    Sonawane, Avinash
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2019, 37 (13): : 3388 - 3398
  • [48] Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with HIV
    Singer, Sarah N.
    Ndumnego, Okechukwu C.
    Kim, Ryung S.
    Ndung'u, Thumbi
    Anastos, Kathryn
    French, Audrey
    Churchyard, Gavin
    Paramithiothis, Eustache
    Kasprowicz, Victoria O.
    Achkar, Jacqueline M.
    EBIOMEDICINE, 2022, 75
  • [49] Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis
    Divneet Kaur
    Shalu Mathew
    Chinchu G. S. Nair
    Azitha Begum
    Ashwin K. Jainanarayan
    Mukta Sharma
    Samir K. Brahmachari
    Journal of Translational Medicine, 15
  • [50] Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis
    Kaur, Divneet
    Mathew, Shalu
    Nair, Chinchu G. S.
    Begum, Azitha
    Jainanarayan, Ashwin K.
    Sharma, Mukta
    Brahmachari, Samir K.
    JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
12345