MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia

被引：11
|
作者：
Devanandan, Helen Jemimah [1 ]
Venkatesan, Vettriselvi [1 ]
Scott, Julius Xavier [2 ]
Magatha, Latha Sneha [2 ]
Paul, Solomon Franklin Durairaj [1 ]
Koshy, Teena [1 ]
机构：
[1] Sri Ramachandra Med Coll & Res Inst, Dept Human Genet, Chennai, Tamil Nadu, India
[2] Sri Ramachandra Med Coll & Res Inst, Dept Pediat Med, Chennai, Tamil Nadu, India
来源：
LABORATORY MEDICINE | 2019年 / 50卷 / 03期
关键词：
microRNA; childhood ALL; rs2910164; rs57095329; haplotype analysis; miR; 146; expression; RISK; GENE;
D O I：
10.1093/labmed/lmy074
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia. Objective: To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL). Method: Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals. Results: No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk. Conclusion: Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
引用
收藏
页码：249 / 253
页数：5
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