MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia

被引：11
|
作者：
Devanandan, Helen Jemimah [1 ]
Venkatesan, Vettriselvi [1 ]
Scott, Julius Xavier [2 ]
Magatha, Latha Sneha [2 ]
Paul, Solomon Franklin Durairaj [1 ]
Koshy, Teena [1 ]
机构：
[1] Sri Ramachandra Med Coll & Res Inst, Dept Human Genet, Chennai, Tamil Nadu, India
[2] Sri Ramachandra Med Coll & Res Inst, Dept Pediat Med, Chennai, Tamil Nadu, India
来源：
LABORATORY MEDICINE | 2019年 / 50卷 / 03期
关键词：
microRNA; childhood ALL; rs2910164; rs57095329; haplotype analysis; miR; 146; expression; RISK; GENE;
D O I：
10.1093/labmed/lmy074
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia. Objective: To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL). Method: Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals. Results: No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk. Conclusion: Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
引用
收藏
页码：249 / 253
页数：5
相关论文
共 50 条
  • [1] Identification Of Single Nucleotide Polymorphisms In MicroRNA 146A
    Weiler, Z.
    Sato, T.
    Nelson, A.
    Liu, X.
    Gunji, Y.
    Muller, K. -C.
    Magnussen, H.
    Rabe, K.
    Rennard, S. I.
    LeVan, T. D.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [2] Association of microRNA Polymorphisms with Toxicities Induced by Methotrexate in Children with Acute Lymphoblastic Leukemia
    Karpa, Vasiliki
    Kalinderi, Kallirhoe
    Fidani, Liana
    Tragiannidis, Athanasios
    HEMATOLOGY REPORTS, 2023, 15 (04) : 634 - 650
  • [3] Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure
    Carman, Kursat Bora
    Karal, Yasemin
    Mert, Gul Gulen
    Ekici, Arzu
    Perk, Peren
    Arslantas, Didem
    Yarar, Coskun
    Dinleyici, Ener Cagri
    TURKISH JOURNAL OF PEDIATRICS, 2021, 63 (04) : 594 - 601
  • [4] The expression of microRNA 146a in patients with ischemic stroke: an observational study
    Kotb, Hend G.
    Ibrahim, Amal H.
    Mohamed, Eman F.
    Ali, Omaima M.
    Hassanein, Nagwa
    Badawy, Dina
    Aly, Ehab Abdelatty
    INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2019, 12 : 273 - 278
  • [5] GENE POLYMORPHISMS IN CRETAN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
    Karathanasis, N.
    Stiakaki, E.
    Goulielmos, G.
    Kalmanti, M.
    HAEMATOLOGICA, 2012, 97 : 485 - 485
  • [6] Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia
    Linga, Vijay Gandhi
    Patchva, Dorra Babu
    Mallavarapu, Krishna Mohan
    Tulasi, Venkata
    Kalpathi, Krishnamani Iyer
    Pillai, Ashok
    Gundeti, Sadashivudu
    Rajappa, Senthil J.
    Digumarti, Raghunadharao
    INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, 2014, 35 (04) : 276 - 280
  • [7] MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL)
    de Oliveira, Jaqueline C.
    Brassesco, Maria Sol
    Scrideli, Carlos Alberto
    Tone, Luiz Gonzaga
    Narendran, Aru
    PEDIATRIC BLOOD & CANCER, 2012, 59 (04) : 599 - 604
  • [8] CONSTITUTIVE HETEROCHROMATIN POLYMORPHISMS IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA
    TSEZOU, A
    KITSIOUTZELI, S
    KOSMIDIS, H
    PAIDOUSI, K
    KATSOUYANNI, K
    SINANIOTIS, C
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1993, 10 (01) : 7 - 11
  • [9] ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia
    Svasdisant, Patpetra
    Glomglao, Waraporn
    Siraprapapat, Preeyanun
    Inthararujikul, Wiyakan
    Tachavanich, Kalaya
    Boonthimat, Chetsada
    Ardsiri, Sakkarin
    Chansing, Kochpinchon
    Sriprach, Suwimon
    Tongsai, Sasima
    Sinlapamongkolkul, Phakatip
    Sanpakit, Kleebsabai
    Buaboonnam, Jassada
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2023, 15
  • [10] OUTCOME OF HIGH HYPERDIPLOIDY IN INDIAN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
    Vasanna, S.
    Radhakrishnan, N.
    Dinand, V.
    Saviour, P.
    Lall, M.
    Sachdeva, A.
    PEDIATRIC BLOOD & CANCER, 2015, 62 : S325 - S325
12345