Risk of cancer in patients with biopsy-proven giant cell arteritis

被引:21
|
作者
Hill, Catherine L. [1 ]
Cole, Antonia [1 ]
Rischmueller, Maureen [1 ]
Dodd, Thomas [2 ]
Coleman, Mark [3 ]
Tucker, Graeme [4 ]
Roberts-Thomson, Peter [5 ]
机构
[1] Queen Elizabeth Hosp, Rheumatol Unit, Woodville, SA 5011, Australia
[2] SA Pathol, Dept Tissue Pathol, Adelaide, SA, Australia
[3] Flinders Med Ctr, Dept Anat Pathol, Bedford Pk, SA, Australia
[4] Dept Hlth, Hlth Stat Unit, Adelaide, SA, Australia
[5] Flinders Med Ctr, Dept Allergy Immunol & Arthritis, Bedford, SA, Australia
关键词
Giant cell arteritis; Malignancy; Epidemiology; Population;
D O I
10.1093/rheumatology/kep409
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Methods. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age-and gender-specific rates for SA. Results. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% Cl 0.8, 1.6). Conclusion. This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.
引用
收藏
页码:756 / 759
页数:4
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