Asymmetric construction of quaternary carbon stereocenter by Pd-hemilabile ligand-catalyzed allylic substitution

被引：15

作者：

Fukuda, Yoshimasa ^{[1
]}

Kondo, Kazuhiro ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 19期

关键词：

asymmetric quaternary carbon; chiral hemilabile ligand; enantioselective Pd-catalyzed allylic substitution;

D O I：

10.1016/j.tetlet.2007.03.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalyst comprised [PdCl(eta(3) -C3H5)](2) and a simple chiral hemilabile ferrocene ligand, 1',2-bis(diphenylphosphinoethyl) ferrocenyl alcohol, provides synthetically acceptable results for an enantioselective Pd-catalyzed allylic alkylation of cyclohexanone derivatives bearing an electron-withdrawing group at the alpha-position to form the quaternary carbon with up to 90% enantioselectivity under mild reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3389 / 3391

页数：3

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