Asymmetric construction of quaternary carbon stereocenter by Pd-hemilabile ligand-catalyzed allylic substitution

被引：15
|
作者：
Fukuda, Yoshimasa [1 ]
Kondo, Kazuhiro [1 ]
Aoyama, Toyohiko [1 ]
机构：
[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 19期
关键词：
asymmetric quaternary carbon; chiral hemilabile ligand; enantioselective Pd-catalyzed allylic substitution;
D O I：
10.1016/j.tetlet.2007.03.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalyst comprised [PdCl(eta(3) -C3H5)](2) and a simple chiral hemilabile ferrocene ligand, 1',2-bis(diphenylphosphinoethyl) ferrocenyl alcohol, provides synthetically acceptable results for an enantioselective Pd-catalyzed allylic alkylation of cyclohexanone derivatives bearing an electron-withdrawing group at the alpha-position to form the quaternary carbon with up to 90% enantioselectivity under mild reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3389 / 3391
页数：3
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