HLA-DR and -DQ alleles in Italian patients with melanoma

被引：0

作者：

Lulli, P

Grammatico, P

Brioli, G

Catricalà, C

Morellini, M

Roccella, M

Mariani, B

Pennesi, G

Roccella, F

Cappellacci, S

Trabace, S

机构：

[1] Univ Rome La Sapienza, Dipartimento Med Sperimentale & Patol, Sez Genet, Rome, Italy

[2] Ist Dermatol S Gallicano, Rome, Italy

来源：

TISSUE ANTIGENS | 1998年 / 51卷 / 03期

关键词：

DQB haplotype; HLA-DQ3; HLA class II; melanoma;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controversial data have been reported about HLA alleles and susceptibility to melanoma. Our investigation was undertaken to analyze the relationship between HLA alleles distribution in patients with melanoma and susceptibility to the tumor, in order to study the possible correlation between HLA class II DQA1, DQB1 and DRB1 genes involved in immune recognition, and melanoma, usually considered a highly immunogenic tumor. We therefore typed by means of PCR-SSP (sequence-specific primers) 53 Italian patients and 53 healthy random controls coming from the same geographic area We observed a decrease of all haplotypes bearing DQB1*0301, DQB1*0302 and DQB1*0303 alleles but not of haplotype DRB1*11;DQA1*0501;DQB1*0301. Our results seem to support the hypo thesis of a protective role of some DQ3-bearing haplotypic combinations in melanoma.

引用

页码：276 / 280

页数：5

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