Association between HLA-DR and DQ alleles and male infertility

被引：0
|
作者：
Alenany, AE [1 ]
Cooke, ID [1 ]
Moore, HD [1 ]
机构：
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield, S Yorkshire, England
来源：
ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS | 2001年
关键词：
D O I：
暂无
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
HLA alleles might predispose to non-immunological male infertility by conferring genetic susceptibility to disorders of spermatogenesis and the genital tract. An investigation was made of the frequency of the HLA-DRB1 and HLA-DQB1 alleles in male partners of infertile couples. Semen samples from 58 patients were used for DNA-based HLA typing using the polymerase chain reaction and sequence specific primers (PCR-SSP). Frequencies of HLA-DRB1*04, 010, 011, 015, 0301 and HLA-DQB1*-03 alleles were found to be significantly higher in oligozoospermic patients than in the control population while the HLA-DRB1*01301 allele was significantly lower. There was no significant association between any of the HLA-DRB 1 or DQB1 alleles and ejaculate sperm density.
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页码：391 / 395
页数：5
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