Methyl methacrylate particles with amino groups on the surface: Colloid stability and sorption of biologically active substances

被引：4

作者：

Baigildin, Vadim ^{[1
,2
]}

Pankova, Galina ^{[1
]}

Evseeva, Tatyana ^{[1
]}

Lavrov, Nikolay ^{[2
]}

Shirokova, Irina ^{[1
]}

Vaganov, Gleb ^{[1
]}

Shevchenko, Natalya ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, Bolshoy Pr VO 31, St Petersburg, Russia

[2] Tech Univ, St Petersburg State Technol Inst, St Petersburg, Russia

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2017年 / 38卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

Amino groups; Biologically active substances; Methyl methacrylate particles; N-VINYLFORMAMIDE; EMULSION POLYMERIZATION; MICROSPHERES; DERIVATIVES; COPOLYMERS; MICROGELS; KINETICS; DEXTRAN; STYRENE; LATEX;

D O I：

10.1080/01932691.2016.1262778

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The present article investigates the influence of dispersion medium on the aggregate stability of cross-linked poly-(methyl methacrylate) particles on the surface layer of which aliphatic amino groups are localized. It is shown that particle size depends on the ionic strength of dispersion medium. The research determines the optimal content of cross-linked agent, ethylene glycol dimetharylate that results in the formation of cationic particles being stable in saline. Particle modification is performed by bovine serum albumin and luminophore fluorescein 5(6)-isothiocyanate. Protein sorption is observed not to influence luminescent properties of the particles. It is also determined that due to the aggregate stability of particles obtained from 5wt% of ethylene glycol dimethacrylate in saline, the monodispersity and the absence of inversion of zeta potential in wide pH range is retained, such particles may be considered as perspective carriers of biologically active substances.

引用

页码：1570 / 1577

页数：8

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