The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

被引：18

作者：

Mohareb, Rafat M. ^{[1
,2
]}

Mohamed, Abeer A. ^{[3
]}

机构：

[1] October Univ Modern Sci & Arts, Dept Organ Chem, Fac Pharm, October City, AR, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza, AR, Egypt

[3] Natl Org Drug Control & Res NODCAR, Cairo, Egypt

来源：

MOLECULES | 2010年 / 15卷 / 05期

关键词：

hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor; HYDRAZONE DERIVATIVES; ANTICONVULSANT ACTIVITY; HYDRAZIDES; SCHIFF; DESIGN; BASES; CELL;

D O I：

10.3390/molecules15053602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.

引用

页码：3602 / 3617

页数：16

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