Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

被引：22

作者：

Wall, Michael D.

Oshin, Michael

Chung, Gavin A. C.

Parkhouse, Tony

Gore, Andrea

Herreros, Esperanza

Cox, Brian

Duncan, Ken

Evans, Brian

Everett, Martin

Mendoza, Alfonso

机构：

[1] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

[3] GlaxoSmithKline, E-28760 Madrid, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 10期

关键词：

Mycobacterium tuberculosis; imidazopiperidines; InhA;

D O I：

10.1016/j.bmcl.2007.02.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2740 / 2744

页数：5

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