Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

被引：22
|
作者：
Wall, Michael D.
Oshin, Michael
Chung, Gavin A. C.
Parkhouse, Tony
Gore, Andrea
Herreros, Esperanza
Cox, Brian
Duncan, Ken
Evans, Brian
Everett, Martin
Mendoza, Alfonso
机构：
[1] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
[3] GlaxoSmithKline, E-28760 Madrid, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 10期
关键词：
Mycobacterium tuberculosis; imidazopiperidines; InhA;
D O I：
10.1016/j.bmcl.2007.02.078
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2740 / 2744
页数：5
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