Cytotoxic activity of iron(III), cobalt(III), nickel(II), zinc(II), and cadmium(II) complexes of 2-acetylpyrazine thiosemicarbazone: crystal structure of the cobalt(III) complex

被引：17

作者：

Zhang, Dong ^{[1
]}

Li, Qian ^{[1
]}

Li, Ming-Xue ^{[1
]}

Chen, Dan-Yun ^{[1
]}

Niu, Jing-Yang ^{[1
]}

机构：

[1] Henan Univ, Inst Mol & Crystal Engn, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 06期

基金：

中国博士后科学基金;

关键词：

2-Acetylpyrazine; Thiosemicarbazone; Metal complexes; Crystal structure; Cytotoxic activity; TRANSITION-METAL-COMPLEXES; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; N(4)-SUBSTITUTED THIOSEMICARBAZONES; SPECTRAL CHARACTERIZATION; PALLADIUM(II) COMPLEXES; COPPER(II) COMPLEXES; ANTITUMOR; SEMICARBAZONES; PLATINUM(II); AGENTS;

D O I：

10.1080/00958971003706706

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Transition metal complexes [Fe(HL)(2)]Cl-3 center dot 1.5H(2)O (1), [Co(L)(2)] center dot ClO4 center dot H2O (2), Ni(HL)(2) (ClO4)(2) center dot 2H(2)O (3), Zn(HL) L center dot BF4 center dot 2H(2)O (4), and Cd(HL)(2)(ClO4)(2) center dot 2H(2)O (5), where HL = C7H9N5S, 2-acetylpyrazine thiosemicarbazone, have been synthesized. Complex 2 was characterized by elemental analysis, infrared spectra, mass spectra, and single-crystal X-ray diffraction. Preliminary in vitro screening showed that 1, 4, and 5 exhibit higher antitumor activity than 2 and 3 against K562 leucocythemia cancer cell line.

引用

页码：1063 / 1070

页数：8

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