A Computational Approach towards the Development of Newer Anticancer Agents

被引：1
|
作者：
Sheikh, Javed I. [1 ]
Juneja, H. D. [1 ]
Ingle, V. N. [1 ]
机构：
[1] RTM Nagpur Univ, Dept Chem, Organ Chem Res Lab, Nagpur 440033, Maharashtra, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 01期
关键词：
Dibenzoylmethane; Cytochrome P450 reductase; In silico docking analysis; MOLECULAR DOCKING; LIVER MICROSOMES; FLEXIBLE DOCKING; CURCUMIN; DIBENZOYLMETHANE; PROTEINS; PROGRAM; TUMORS; MICE;
D O I：
10.1155/2010/582710
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In silico molecular docking analyses of the novel 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-aryl-propane-1, 3-diones were performed in the active sites of enzyme cytochrome P450 reductase to obtain new anticancer agents computationally. 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-(4 ''-methoxyphenyl)-propane-1, 3-dione (3f) was found to have maximum affinity for the active sites of enzyme.
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页码：21 / 24
页数：4
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