Differential expression of multidrug resistance genes in naive rat brain

被引：33
|
作者：
Kwan, P
Sills, GJ [1 ]
Butler, E
Gant, TW
Brodie, MJ
机构：
[1] Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland
[2] Univ Leicester, MRC, Toxicol Unit, Leicester, Leics, England
来源：
NEUROSCIENCE LETTERS | 2003年 / 339卷 / 01期
关键词：
multidrug resistance; P-glycoprotein; quantitative reverse-transcriptase polymerase chain reaction; brain; rat;
D O I：
10.1016/S0304-3940(02)01453-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The multidrug resistance (mdr1) gene family encodes the efflux transporter P-glycoprotein (P-gp) which contributes to the functionality of the blood-brain barrier. We have characterised the regional expression of mdr1 genes in naive rat brain. Adult male Sprague-Dawley rats (n = 6) were sacrificed and their brains rapidly removed. Seven distinct anatomical regions were isolated by microdissection and the expression of mdr1a and mdr1b determined by quantitative reverse-transcriptase polymerase chain reaction. The mdr1a isoform was expressed in all brain regions investigated, while mdr1b was expressed to a quantifiable degree in hippocampus alone. These findings reveal a differential expression of mdr1 genes in normal rodent brain tissue and suggest that P-gp may afford a broader protection of the hippocampus than other brain structures. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码：33 / 36
页数：4
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