Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies

被引：92

作者：

Moody, M. Anthony ^{[1
,2
,3
]}

Pedroza-Pacheco, Isabela ^{[4
]}

Vandergrift, Nathan A. ^{[1
,5
]}

Chui, Cecilia ^{[4
]}

Lloyd, Krissey E. ^{[1
]}

Parks, Robert ^{[1
]}

Soderberg, Kelly A. ^{[1
]}

Ogbe, Ane T. ^{[4
]}

Cohen, Myron S. ^{[6
]}

Liao, Hua-Xin ^{[1
,5
]}

Gao, Feng ^{[1
,5
]}

McMichael, Andrew J. ^{[4
]}

Montefiori, David C. ^{[7
]}

Verkoczy, Laurent ^{[1
,5
,8
]}

Kelsoe, Garnett ^{[1
,2
]}

Huang, Jinghe ^{[9
]}

Shea, Patrick R. ^{[10
]}

Connors, Mark ^{[9
]}

Borrow, Persephone ^{[4
]}

Haynes, Barton F. ^{[1
,2
,5
]}

机构：

[1] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC 27710 USA

[2] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27710 USA

[3] Duke Univ, Sch Med, Dept Pediat, Durham, NC 27710 USA

[4] Univ Oxford, Nuffield Dept Clin Med, Oxford OX3 7FZ, England

[5] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

[6] Univ North Carolina Chapel Hill, Chapel Hill, NC 27599 USA

[7] Duke Univ, Sch Med, Dept Surg, Durham, NC 27710 USA

[8] Duke Univ, Sch Med, Dept Pathol, Durham, NC 27710 USA

[9] NIAID, Lab Immunoregulat, NIH, Bethesda, MD 20814 USA

[10] Columbia Univ, Inst Genom Med, New York, NY 10032 USA

来源：

SCIENCE IMMUNOLOGY | 2016年 / 1卷 / 01期

关键词：

T FOLLICULAR HELPER; SIMIAN IMMUNODEFICIENCY VIRUS; B-CELL ACTIVATION; GERMINAL CENTER; ENVELOPE GLYCOPROTEINS; HIV-1; INFECTION; RHESUS MACAQUES; RESPONSES; TOLERANCE; REGION;

D O I：

10.1126/sciimmunol.aag0851

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1- infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4(+) T cells, a higher frequency of circulating memory T follicular helper CD4(+) cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.

引用

页数：10

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