Elevated exhalation of hydrogen peroxide in patients with systemic sclerosis

被引:25
|
作者
Luczyñska, M
Szkudlarek, U
Dziankowska-Bartkowiak, B
Waszczykowska, E
Kasielski, M
Sysa-Jèdrzejowska, A
Nowak, D
机构
[1] Med Univ Lodz, Dept Expt & Clin Physiol, Inst Physiol & Biochem, PL-92215 Lodz, Poland
[2] Med Univ Lodz, Dept Dermatol, PL-92215 Lodz, Poland
[3] Med Univ Lodz, Pract Clin Training Ctr, PL-92215 Lodz, Poland
关键词
expired breath condensate; hydrogen peroxide; systemic sclerosis;
D O I
10.1046/j.1365-2362.2003.01138.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Systemic sclerosis is accompanied by an influx of activated phagocytes into distal airways. These cells release H-2 O-2 , which may evaporate from the airways surface and be detected in expired breath condensate. We tested whether patients with systemic sclerosis exhale more H-2 O-2 than healthy subjects and whether breath condensate H-2 O-2 levels correlate with some clinical parameters. Materials and methods H-2 O-2 was measured fluorimetrically in the expired breath condensate of 27 patients (22 women, five men, mean age 49 +/- 13.1 years) with systemic sclerosis and 27 age- and sex- matched healthy controls. Results Exhaled H-2 O-2 levels were 3.5-fold higher (0.88 +/- 0.62 muM vs. 0.25 +/- 0.17 muM, P < 0.001) in the patients with systemic sclerosis than in the controls. Treatment with cyclophosphamide and/or prednisone (29 +/- 50 months, range 3-168 months) did not significantly decrease H-2 O-2 exhalation (0.78 +/- 0.50 muM, n = 10 vs. 0.94 +/- 0.67 muM, n = 17, P > 0.05). No significant difference was found between patients with limited and diffuse scleroderma (1.03 +/- 0.69 muM, n = 17 vs. 0.63 +/- 0.41 muM, n = 10, P > 0.05). H-2 O-2 levels correlated with disease duration (r = 0.38, P < 0.05) and time from the first Raynaud's episode (r = 0.44, P < 0.05). Conclusions Patients with systemic sclerosis exhale more H-2 O-2 than healthy controls, suggesting involvement of reactive oxygen species in disease processes. Lack of significant intergroups differences in H-2 O-2 levels may have resulted from the small number of patients analyzed.
引用
收藏
页码:274 / 279
页数:6
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