Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study

被引:6
|
作者
Li, Xu [1 ,2 ]
Xu, Hongqin [1 ,3 ]
Gao, Pujun [1 ,2 ]
机构
[1] Jilin Univ, Hosp 1, Dept Hepatol, 71 Xinmin St, Changchun 130021, Peoples R China
[2] Jilin Univ, Key Lab Organ Regenerat & Transplantat, Hosp 1, Minist Educ, Changchun 130061, Peoples R China
[3] Jilin Prov Key Lab Infect Dis, Lab Mol Virol, Changchun 130021, Peoples R China
关键词
D O I
10.1038/s41598-020-80116-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We used a retrospective study design to evaluated the predictive value of red cell distribution width (RDW) for drug-induced liver injury (DILI) severity in Chinese patients with liver biopsy to assist with early DILI management. We included 164 DILI patients with complete laboratory information and medical history. We compared outcomes of 36 patients with severe DILI with outcomes of a control group of 128 patients with mild-to-moderate DILI. Multivariate analyses of risk factors for severe liver injury in Chinese patients with DILI revealed an estimated adjusted odds ratio (AOR) (95% CI) of 4.938 (1.088-22.412) in patients with drinking. Risk for serious liver injury was also increased significantly in patients with dyslipidemia [AOR (95% CI) 3.926 (1.282-12.026)], higher serum total bile acid (TBA) levels [AOR (95% CI) 1.014 (1.009-1.020)] and higher RDW [AOR (95% CI) 1.582 (1.261-1.986)]. The result for area under the curve of 0.905 for TBA levels indicated this variable had high diagnostic performance for predicting DILI severity. Based on an area under the curve value of 0.855, RDW also had superior diagnostic performance in prediction of DILI severity. This performance was not significantly different compared with TBA and was superior compared with other variables, which had area under values ranging from poor to failure (0.527-0.714).The risk for severe DILI was associated with drinking, dyslipidemia, higher TBA levels and RDW values. This study found that RDW and TBA levels were predictors of DILI severity in Chinese patients.
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页数:8
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