Synthesis of new indenoisoquinolines: Cytotoxic agents and topoisomerase I inhibitors.

被引:0
|
作者
Ioanoviciu, AS
Antony, S
Pommier, Y
Cushman, M
机构
[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
[2] NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
116-MEDI
引用
收藏
页码:U27 / U27
页数:1
相关论文
共 50 条
  • [41] Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I
    Elsayed, Mohamed S. A.
    Su, Yafan
    Wang, Ping
    Sethi, Taresh
    Agama, Keli
    Ravji, Azhar
    Redon, Christophe E.
    Kiselev, Evgeny
    Horzmann, Katharine A.
    Freeman, Jennifer L.
    Pommier, Yves
    Cushman, Mark
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (13) : 5364 - 5376
  • [42] Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors
    Guan, J
    Zhu, XK
    Tachibana, Y
    Bastow, KF
    Brossi, A
    Hamel, E
    Lee, KH
    BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (11) : 2127 - 2131
  • [43] Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents
    Vicker, N
    Burgess, L
    Chuckowree, IS
    Dodd, R
    Folkes, AJ
    Hardick, DJ
    Hancox, TC
    Miller, W
    Milton, J
    Sohal, S
    Wang, SM
    Wren, SP
    Charlton, PA
    Dangerfield, W
    Liddle, C
    Mistry, P
    Stewart, AJ
    Denny, WA
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (03) : 721 - 739
  • [44] Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
    Nagarajan, Muthukaman
    Morrell, Andrew
    Antony, Smitha
    Kohlhagen, Glenda
    Agama, Keli
    Pommier, Yves
    Ragazzon, Patricia A.
    Garbett, Nichola C.
    Chaires, Jonathan B.
    Hollingshead, Melinda
    Cushman, Mark
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (17) : 5129 - 5140
  • [45] SYNTHESIS AND EVALUATION OF TERBENZIMIDAZOLES AS TOPOISOMERASE-I INHIBITORS
    SUN, Q
    GATTO, B
    YU, C
    LIU, A
    LIU, LF
    LAVOIE, EJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (18) : 3638 - 3644
  • [46] Topoisomerase IIβ mediates the cytotoxicity of topoisomerase II poisons in the presence of HDAC inhibitors.
    Marchion, DC
    Bicaku, E
    Turner, JG
    Daud, AI
    Sullivan, DM
    Munster, PN
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9021S - 9021S
  • [47] Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
    Xiao, XS
    Antony, S
    Kohlhagen, G
    Pommier, Y
    Cushman, M
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (19) : 5147 - 5160
  • [48] Topoisomerase I inhibitors
    Saijo, Nagahiro
    JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (08) : S172 - S173
  • [49] In vitro sensitivity of human HaCaT keratinocytes to topoisomerase inhibitors.
    Pessina, A
    Cerri, A
    Piccirillo, M
    Raimondi, A
    Berti, E
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (04) : 527 - 527
  • [50] Recent developments of rebeccamycin analogues as topoisomerase I inhibitors and antitumor agents
    Prudhomme, M
    CURRENT MEDICINAL CHEMISTRY, 2000, 7 (12) : 1189 - 1212