A method for measuring nitric oxide radical scavenging activity. Scavenging properties of sulfur-containing compounds

被引：27
|
作者：
Vriesman, MF [1 ]
Haenen, GRMM [1 ]
Westerveld, GJ [1 ]
Paquay, JBG [1 ]
Voss, HP [1 ]
Bast, A [1 ]
机构：
[1] Vrije Univ Amsterdam, Fac Chem, Dept Pharmacochem, Leiden Amsterdam Ctr Drug Res,Div Mol Pharmacol, NL-1081 HV Amsterdam, Netherlands
来源：
PHARMACY WORLD & SCIENCE | 1997年 / 19卷 / 06期
关键词：
nitric oxide radical; NO scavenging; thiol; S-nitrosothiol (electrochemical); NO sensing;
D O I：
10.1023/A:1008601327920
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new method for the quantificatiion of the nitric oxide ((NO)-N-.) scavenging activity of compounds in aqueous solutions is describing using an amperometric (NO)-N-. sensor. After correction for the spontaneous degradation of (NO)-N-., second-order rate kinetics of the scavenging reactions are observe. The rate constant for hemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable (NO)-N-. scavenging activity.
引用
收藏
页码：283 / 286
页数：4
相关论文
共 50 条
  • [21] Antioxidant Activity and Free Radical Scavenging Properties of Captopril
    Asori, Mohsen
    Hedayatizadeh-Omran, Akbar
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (08) : 3713 - 3715
  • [22] Tyrosinase Inhibition, Super Oxide Anion and Nitric Oxide Radical Scavenging Properties of Artemisia absinthium Essential Oil
    Taherkhani, Tofigh
    Zakaria, Rasool Asghari
    Taherkhani, Mahboubeh
    Rustaiyan, Abdolhossein
    JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, 17 (06) : 1057 - 1063
  • [23] Kinetics of the radical scavenging activity of β-carotene-related compounds
    Fujisawa, S
    Ishihara, M
    Kadoma, Y
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2004, 15 (01) : 33 - 41
  • [24] Nitric oxide-scavenging properties of some chalcone derivatives
    Herencia, F
    López-Garcia, MP
    Ubeda, A
    Ferrándiz, ML
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2002, 6 (02): : 242 - 246
  • [25] Phytochemical analysis with free radical scavenging, nitric oxide inhibition and antiproliferative activity of Sarcocephalus pobeguinii extracts
    Njoya, Emmanuel Mfotie
    Munvera, Aristide Mfifen
    Mkounga, Pierre
    Nkengfack, Augustin Ephrem
    McGaw, Lyndy Joy
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17
  • [26] Detection of nitric oxide radical and determination of its scavenging activity by antioxidants using spectrophotometric and spectrofluorometric methods
    Can, Ziya
    Keskin, Busra
    Uzer, Aysem
    Apak, Resat
    TALANTA, 2022, 238
  • [27] Development of reliable spin trapping method for measuring OH radical-scavenging activity of antioxidants
    Yoshioka, H.
    KURRI Progress Report, 2000,
  • [28] Phytochemical analysis with free radical scavenging, nitric oxide inhibition and antiproliferative activity of Sarcocephalus pobeguinii extracts
    Emmanuel Mfotie Njoya
    Aristide Mfifen Munvera
    Pierre Mkounga
    Augustin Ephrem Nkengfack
    Lyndy Joy McGaw
    BMC Complementary and Alternative Medicine, 17
  • [29] Antioxidant, nitric oxide scavenging and malondialdehyde scavenging activity of essential oils from different chemotypes of Zataria multiflora
    Karinian, Parastoo
    Kavoosi, Gholamreza
    CLINICAL BIOCHEMISTRY, 2011, 44 (13) : S339 - S339
  • [30] Radical scavenging activity and inhibition of fish oil oxidation by garlic compounds
    Yamaya, Yoshifumi
    Hosokawa, Masashi
    Miyashita, Kazuo
    JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 2022, 69 (12): : 549 - 555
12345