Phagocytic Activity of Macrophages against Liposomes with Conjugates of Oxidized Dextrans and Isonicotinic Acid Hydrazide during Modeling of Phagocytosis Disturbances In Vitro

被引：0

作者：

Arkhipov, S. A. ^{[1
]}

Shkurupy, V. A. ^{[1
]}

Troitsky, A. V. ^{[1
]}

Luzgina, N. G. ^{[1
]}

Ufimceva, E. G. ^{[1
]}

Zaikovskaja, M. V. ^{[1
]}

Iljine, D. A. ^{[1
]}

Akhramenko, E. S. ^{[1
]}

Gulyaeva, E. P. ^{[1
]}

Bistrova, T. N. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 148卷 / 04期

关键词：

oxidized dextrans; isonicotinic acid hydrazide; liposomes; phagocytosis; macrophages;

D O I：

10.1007/s10517-010-0795-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied phagocytic activity of macrophages against molecular-liposome hybrid compositions consisting of liposomes (diameter 200-450 nm) containing oxidized dextrans with a molecular weight of 35 or 60 kDa conjugated with the basic antituberculosis preparation isonicotinic acid hydrazide (dextrazides) during modeling of various disturbances of endocytosis function of phagocytic cells in vitro. Preincubation of macrophages with trypsin, colchicine, or sodium azide did not change the parameters of adhesion of molecular-liposome hybrid compositions to macrophages. It was found that preincubation of cells with colchicine or sodium azide reduced parameters of phagocytosis of the molecular-liposome hybrid compositions; this reduction did not depend on the molecular weight of dextrans entering the composition of the molecular-liposome hybrid compositions.

引用

页码：689 / 691

页数：3

共 7 条

[1] Phagocytic Activity of Macrophages against Liposomes with Conjugates of Oxidized Dextrans and Isonicotinic Acid Hydrazide during Modeling of Phagocytosis Disturbances In Vitro
S. A. Arkhipov
V. A. Shkurupy
A. V. Troitsky
N. G. Luzgina
E. G. Ufimceva
M. V. Zaikovskaja
D. A. Iljine
E. S. Akhramenko
E. P. Gulyaeva
T. N. Bistrova
Bulletin of Experimental Biology and Medicine, 2009, 148 : 689 - 691
[2] Phagocytosis of Hybrid Molecular Nanosomal Compositions Containing Oxidized Dextrans Conjugated with Isonicotinic Acid Hydrazide by Macrophages
Shkurupy, V. A.
Arkhipov, S. A.
Troitsky, A. V.
Luzgina, N. G.
Zaikovskaja, M. V.
Ufimceva, E. G.
Iljine, D. A.
Akhramenko, E. S.
Gulyaeva, E. P.
Bistrova, T. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2009, 148 (06) : 874 - 876
[3] Phagocytosis of Hybrid Molecular Nanosomal Compositions Containing Oxidized Dextrans Conjugated with Isonicotinic Acid Hydrazide by Macrophages
V. A. Shkurupy
S. A. Arkhipov
A. V. Troitsky
N. G. Luzgina
M. V. Zaikovskaja
E. G. Ufimceva
D. A. Iljine
E. S. Akhramenko
E. P. Gulyaeva
T. N. Bistrova
Bulletin of Experimental Biology and Medicine, 2009, 148 : 874 - 876
[4] In Vitro Effects of Molecular Nanosomal Hybrid Compositions with Oxidized Dextrans, Conjugated with Isonicotinic Acid Hydrazine on Peritoneal Macrophages
Shkurupy, V. A.
Arkhipov, S. A.
Tkachev, V. O.
Troitsky, A. V.
Luzgina, N. G.
Zaikovskaja, M. V.
Gulyaeva, E. P.
Bistrova, T. N.
Ufimtceva, E. G.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (05) : 627 - 629
[5] In Vitro Effects of Molecular Nanosomal Hybrid Compositions with Oxidized Dextrans, Conjugated with Isonicotinic Acid Hydrazine on Peritoneal Macrophages
V. A. Shkurupy
S. A. Arkhipov
V. O. Tkachev
A. V. Troitsky
N. G. Luzgina
M. V. Zaikovskaja
E. P. Gulyaeva
T. N. Bistrova
E. G. Ufimtceva
Bulletin of Experimental Biology and Medicine, 2008, 146 : 627 - 629
[6] Effects of Molecular Liposomal Hybrid Compositions with Oxidized Dextrans and Isonicotinic Acid Hydrazide on Production of Granulocytic Macrophage Colony-Stimulating Factor by Macrophages
Shkurupy, V. A.
Arkhipov, S. A.
Troitsky, A. V.
Luzgina, N. G.
Zaikovskaja, M. V.
Ufimceva, E. G.
Iljine, D. A.
Akhramenko, E. S.
Gulyaeva, E. P.
Bistrova, T. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2009, 148 (04) : 710 - 712
[7] Effects of Molecular Liposomal Hybrid Compositions with Oxidized Dextrans and Isonicotinic Acid Hydrazide on Production of Granulocytic Macrophage Colony-Stimulating Factor by Macrophages
V. A. Shkurupy
S. A. Arkhipov
A. V. Troitsky
N. G. Luzgina
M. V. Zaikovskaja
E. G. Ufimceva
D. A. Iljine
E. S. Akhramenko
E. P. Gulyaeva
T. N. Bistrova
Bulletin of Experimental Biology and Medicine, 2009, 148 : 710 - 712

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