Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin

被引：25

作者：

Takehara, Masaya ^{[1
]}

Takagishi, Teruhisa ^{[1
]}

Seike, Soshi ^{[2
]}

Oda, Masataka ^{[3
]}

Sakaguchi, Yoshihiko ^{[4
]}

Hisatsune, Junzo ^{[5
]}

Ochi, Sadayuki ^{[6
]}

Kobayashi, Keiko ^{[1
]}

Nagahama, Masahiro ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Dept Microbiol, Yamashiro, Tokushima 7708514, Japan

[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Mol Microbiol Sci, Kure, Hiroshima 7370112, Japan

[3] Kyoto Pharmaceut Univ, Dept Microbiol & Infect Control Sci, Kyoto 6078414, Japan

[4] Kitasato Univ, Dept Microbiol, Sch Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520374, Japan

[5] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Bacteriol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan

[6] Yokohama Univ Pharm, Fac Pharm, Totsuka Ku, 601 Matano Cho, Yokohama, Kanagawa 2450066, Japan

来源：

TOXINS | 2017年 / 9卷 / 08期

关键词：

clostridial binary toxin; iota-toxin; C2; toxin; cellular internalization; PLASMA-MEMBRANE REPAIR; ARGININE ADP-RIBOSYLATION; BINARY TOXINS; INTRACELLULAR TRAFFICKING; ENZYMATIC COMPONENTS; BIOLOGICAL-ACTIVITY; BINDING-COMPONENT; MAMMALIAN-CELLS; LIPID RAFTS; VERO CELLS;

D O I：

10.3390/toxins9080247

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-rafts, mediating the uptake of the enzymatic component into the cytosol. Enzymatic components induce actin cytoskeleton disorganization through the ADP-ribosylation of actin and are responsible for cell rounding and death. This review focuses upon the recent advances in cellular internalization of clostridial binary toxins.

引用

页数：9

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