Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin

被引：25
|
作者：
Takehara, Masaya [1 ]
Takagishi, Teruhisa [1 ]
Seike, Soshi [2 ]
Oda, Masataka [3 ]
Sakaguchi, Yoshihiko [4 ]
Hisatsune, Junzo [5 ]
Ochi, Sadayuki [6 ]
Kobayashi, Keiko [1 ]
Nagahama, Masahiro [1 ]
机构：
[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Dept Microbiol, Yamashiro, Tokushima 7708514, Japan
[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Mol Microbiol Sci, Kure, Hiroshima 7370112, Japan
[3] Kyoto Pharmaceut Univ, Dept Microbiol & Infect Control Sci, Kyoto 6078414, Japan
[4] Kitasato Univ, Dept Microbiol, Sch Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520374, Japan
[5] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Bacteriol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan
[6] Yokohama Univ Pharm, Fac Pharm, Totsuka Ku, 601 Matano Cho, Yokohama, Kanagawa 2450066, Japan
来源：
TOXINS | 2017年 / 9卷 / 08期
关键词：
clostridial binary toxin; iota-toxin; C2; toxin; cellular internalization; PLASMA-MEMBRANE REPAIR; ARGININE ADP-RIBOSYLATION; BINARY TOXINS; INTRACELLULAR TRAFFICKING; ENZYMATIC COMPONENTS; BIOLOGICAL-ACTIVITY; BINDING-COMPONENT; MAMMALIAN-CELLS; LIPID RAFTS; VERO CELLS;
D O I：
10.3390/toxins9080247
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-rafts, mediating the uptake of the enzymatic component into the cytosol. Enzymatic components induce actin cytoskeleton disorganization through the ADP-ribosylation of actin and are responsible for cell rounding and death. This review focuses upon the recent advances in cellular internalization of clostridial binary toxins.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] DE-ADP-RIBOSYLATION ACTIN BY CLOSTRIDIUM-PERFRINGENS IOTA-TOXIN AND CLOSTRIDIUM-BOTULINUM C2 TOXIN
    JUST, I
    GEIPEL, U
    WEGNER, A
    AKTORIES, K
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 192 (03): : 723 - 727
  • [2] Cellular uptake of the Clostridium perfringens binary iota-toxin
    Blöcker, D
    Behlke, J
    Aktories, K
    Barth, H
    INFECTION AND IMMUNITY, 2001, 69 (05) : 2980 - 2987
  • [3] Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin
    Nagahama, Masahiro
    Takehara, Masaya
    Seike, Soshi
    Sakaguchi, Yoshihiko
    TOXINS, 2023, 15 (12)
  • [4] Clostridium perfringens Iota-Toxin: Structure and Function
    Sakurai, Jun
    Nagahama, Masahiro
    Oda, Masataka
    Tsuge, Hideaki
    Kobayashi, Keiko
    TOXINS, 2009, 1 (02): : 208 - 228
  • [5] Substrate specificity of actin-ADP-ribosylation by Clostridium perfringens iota toxin and Clostridium botulinum C2 toxin
    Hochmann, H
    Schleberger, C
    Schulz, GE
    Aktories, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2006, 372 : 125 - 126
  • [6] EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
    Schnell, Leonie
    Mittler, Ann-Katrin
    Sadi, Mirko
    Popoff, Michel R.
    Schwan, Carsten
    Aktories, Klaus
    Mattarei, Andrea
    Tehran, Domenico Azarnia
    Montecucco, Cesare
    Barth, Holger
    TOXINS, 2016, 8 (04):
  • [7] Acid Sphingomyelinase Promotes Cellular Internalization of Clostridium perfringens Iota-Toxin
    Nagahama, Masahiro
    Takehara, Masaya
    Miyamoto, Kazuaki
    Ishidoh, Kazumi
    Kobayashi, Keiko
    TOXINS, 2018, 10 (05):
  • [8] CHARACTERIZATION OF THE ADP-RIBOSYLATION OF ACTIN BY CLOSTRIDIUM-BOTULINUM C2 TOXIN AND CLOSTRIDIUM-PERFRINGENS IOTA TOXIN
    AKTORIES, K
    GEIPEL, U
    WILLE, M
    JUST, I
    JOURNAL DE PHYSIOLOGIE, 1990, 84 (04): : 262 - 266
  • [9] Intracellular Trafficking of Clostridium perfringens Iota-Toxin b
    Nagahama, Masahiro
    Umezaki, Mariko
    Tashiro, Ryo
    Oda, Masataka
    Kobayashi, Keiko
    Shibutani, Masahiro
    Takagishi, Teruhisa
    Ishidoh, Kazumi
    Fukuda, Mitsunori
    Sakurai, Jun
    INFECTION AND IMMUNITY, 2012, 80 (10) : 3410 - 3416
  • [10] Characterization of the enzymatic component of Clostridium perfringens iota-toxin
    Nagahama, M
    Sakaguchi, Y
    Kobayashi, K
    Ochi, S
    Sakurai, J
    JOURNAL OF BACTERIOLOGY, 2000, 182 (08) : 2096 - 2103
12345