Type I and type II T-cell profiles in aplastic anemia and refractory anemia

被引：6
|
作者：
Tsuda, H [1 ]
Yamasaki, H [1 ]
机构：
[1] Kumamoto City Hosp, Div Clin Hematol & Immunol, Kumamoto 8628505, Japan
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 2000年 / 64卷 / 04期
关键词：
pathogenesis; immune mechanism; T-cell subset; aplastic anemia; myelodysplastic syndrome; refractory anemia;
D O I：
10.1002/1096-8652(200008)64:4<271::AID-AJH6>3.0.CO;2-C
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immune-mediated suppression of hematopoiesis has been considered the most important mechanism in the development of idiopathic aplastic anemia (AA) and some types of myelodysplastic syndrome (MDS). Using flow cytometric analysis of intracellular cytokine expression at the single-cell level, we analyzed helper-T (Th) and cytotoxic-T (Tc) subsets in patients with AA and MDS of refractory anemia (RA) subtype. The results showed marked increases in the Th1/Th2 ratio and Tc1/Tc2 ratio in both AA and MDS/RA. Overproduction of cytokines inhibitory to hematopoiesis reported so far might be a reflection of imbalanced development of Th and Tc. Determination of the factors that affect Th and Tc profiles may lead to further understanding of immunological states and the development of effective immunotherapy in AA as well as some types of MDS. Am. J. Hematol. 64:271-274, 2000. (C) 2000 Wiley-Liss, Inc.
引用
收藏
页码：271 / 274
页数：4
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