Clinical pharmacokinetics and interaction of centchroman - A mini review

被引：47
|
作者：
Lal, Jawahar [1 ]
机构：
[1] Cent Drug Res Inst, CSIR, Pharmacokinet & Metab Div, Lucknow 226001, Uttar Pradesh, India
来源：
CONTRACEPTION | 2010年 / 81卷 / 04期
关键词：
Centchroman; Ormeloxifene; Selective estrogen receptor modulator; Pharmacokinetics; Drug drug interaction; ENDOMETRIAL SENSITIVITY; TRIPHENYLETHYLENE ANTIESTROGEN; PINOPOD DEVELOPMENT; NIDATORY ESTROGEN; PLASMA-PROTEINS; RHESUS-MONKEY; BREAST-MILK; FEMALE RATS; HUMAN-SERUM; BINDING;
D O I：
10.1016/j.contraception.2009.11.007
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：275 / 280
页数：6
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