Synthesis of phthalic acid derivatives via Pd-catalyzed alkoxycarbonylation of aromatic C-H bonds with alkyl chloroformates

被引：22
|
作者：
Liao, Gang [1 ]
Chen, Hao-Ming [2 ]
Shi, Bing-Feng [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
[2] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 77期
关键词：
CARBON-HYDROGEN BONDS; OXIDATIVE CARBONYLATION; ORTHO-ETHOXYCARBONYLATION; DIETHYL AZODICARBOXYLATE; UNACTIVATED C(SP(3))-H; ROOM-TEMPERATURE; DIRECTING GROUP; ACTIVATION; FUNCTIONALIZATION; RUTHENIUM;
D O I：
10.1039/c8cc06663a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Pd(ii)-catalyzed alkoxycarbonylation of aromatic C-H bonds with alkyl chloroformates has been developed. A broad range of benzamides and alkyl chloroformates are compatible with this protocol. The reaction is operationally simple and scalable. The direct group could be readily removed to access substituted phthalic acid esters (PAEs), 1,2-dibenzyl alcohols and phthalamides. Besides alkoxycarbonylation of benzamide -C-H bonds, -alkoxycarbonylation of 2-phenylacetamide is also feasible.
引用
收藏
页码：10859 / 10862
页数：4
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