Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity

被引：8
|
作者：
Feng, Zheling [1 ]
Chen, Shixin [2 ]
Wang, Wei [3 ]
Feng, Lu [4 ,5 ]
Dong, Yanyan [6 ]
Zou, Yiping [6 ]
Ke, Changqiang [4 ,5 ]
Tang, Chunping [4 ,5 ]
Yao, Sheng [4 ,5 ]
Zhang, Haiyan [3 ]
Gan, Lishe [2 ]
Ye, Yang [4 ,5 ,7 ]
Lin, Ligen [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310007, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Long Res, Shanghai 201203, Peoples R China
[5] Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
[6] Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Jiangxi, Peoples R China
[7] Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
来源：
FITOTERAPIA | 2019年 / 139卷
基金：
中国国家自然科学基金;
关键词：
Lycopodiastrum casuarinoides; Lycopodiaceae; Lycodine-type alkaloids; TD-DFT; ECD; ALZHEIMERS-DISEASE; HUPERZINE;
D O I：
10.1016/j.fitote.2019.104378
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five previously undescribed lycodine-type alkaloids, named huperzine Y (1), 8,15-epoxy-N-demethylhuperzinine (2), 7-hydroxyl-huperzinine (3), huperzine Z (4), and huperzine D N-oxide (5), were isolated from the aerial parts and roots of Lycopodiastrum casuarinoides (Lycopodiaceae), along with ten known analogues. The structures of the new compounds were elucidated by means of spectroscopic technique (IR, UV, MS and NMR). The absolute configurations of the new compounds were established on the basis of comparison of their experimental and TD-DFT (time-dependent density functional theory) calculated ECD spectra. Moreover, all the isolates were evaluated for acetylcholinesterase (AChE) inhibitory activity. Only huperzine C showed moderate activity, with an IC50 value of 0.525 +/- 0.140 mu M, which was comparable with the positive control, huperzine A (IC50 = 0.143 +/- 0.029 mu M).
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页数：7
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