Appendectomy protects against ulcerative colitis

被引：34

作者：

Derby, LE ^{[1
]}

Jick, H ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA 02173 USA

来源：

EPIDEMIOLOGY | 1998年 / 9卷 / 02期

关键词：

prior appendectomy; ulcerative colitis; protective effect;

D O I：

10.1097/00001648-199803000-00018

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We conducted a case-control study of the protective effect of appendectomy on the development of ulcerative colitis. We calculated the risk of ulcerative colitis in 716 incident cases of ulcerative colitis and 2,747 controls according to appendectomy status, using data from the United Kingdom General Practice Research Database. We also studied a random sample of 100 cases and 100 controls to validate the subject's history of appendectomy. Fifteen cases (2%) and 109 (4%) controls had a computer-recorded history of appendectomy [odds ratio (OR) = 0.5; 95% confidence interval (CI) = 0.3-0.9]. In the sample, the OR was 0.3 (95% CI = 0.1-0.9). Appendectomy appears to protect against ulcerative colitis.

引用

页码：205 / 207

页数：3

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