Aggression in ADHD: relation to salivary cortisol

被引:1
|
作者
El Ghamry, Reem H. [1 ]
Mohamed, Mona M. [1 ]
Azzam, Hanan M. [1 ]
Elhabiby, Mahmoud M. [1 ]
Hasan, Haytham M. [2 ]
Hashish, Adel F. [3 ]
Elhamshary, Mohammed M. [4 ]
Barakat, Doaa M. H. [1 ]
机构
[1] Ain Shams Univ, Fac Med, Okasha Inst Psychiat, 22 Dair Almalak, Cairo 11657, Egypt
[2] Helwan Univ, Fac Med, Helwan, Egypt
[3] Natl Res Ctr, Ctr Excellence Med Res, Med Div, Cairo, Egypt
[4] Cumbria Northumberland Tyne & Wear NHS Fdn Trust, Northumberland Tyne & Wear NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England
来源
关键词
ADHD; Aggression; Salivary cortisol; Attention deficit; Hyperactivity; DEFICIT HYPERACTIVITY DISORDER; PITUITARY-ADRENAL AXIS; ADOLESCENT BOYS; ATTENTION; CHILDREN; STRESS; NEUROENDOCRINE; ASSOCIATIONS; MALTREATMENT; VALIDATION;
D O I
10.1186/s43045-021-00104-w
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Study of cortisol levels in patients with ADHD in correlation with aggressive behaviors associated with ADHD has received limited research attention. This factor is essential for comprehending the psychopathophysiology of ADHD and its comorbidities. The present study aimed to investigate the cortisol level in ADHD children and its relation to severity of symptoms and associated aggressive behavior in those children. The sample consisted of 129 patients and 80 healthy controls evaluated by administering the Mini International Neuropsychiatric Interview for Children, The Wechsler Intelligence Scale for Children, Conners' parent rating scale, problem scale of C.B.C.L., and Socioeconomic Status Scale. Salivary cortisol was measured using radio-immune assay. Results Salivary cortisol level in our ADHD subjects was significantly lower (11.826 ng/ml) than in the control group (19.619 ng/ml with P-value 0.001). Our results failed to find any correlation between ADHD symptoms severity and salivary cortisol levels. Severity of delinquent, aggressive, and externalizing behaviors of ADHD children positively correlated with cortisol salivary levels. Conclusion Salivary cortisol levels are lower in children with ADHD relative to age- and sex-matched healthy controls. In addition, there is no obvious correlation between severity of ADHD symptoms and basal salivary cortisol levels. We also concluded that there is positive correlation between delinquent, aggressive, and externalizing behaviors in children with ADHD and their basal salivary cortisol levels.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] Testosterone and Cortisol in Relation to Aggression in a Non-Clinical Sample of Boys and Girls
    Platje, Evelien
    Popma, Arne
    Vermeiren, Robert R. J. M.
    Doreleijers, Theo A. H.
    Meeus, Wim H. J.
    van Lier, Pol A. C.
    Koot, Hans M.
    Branje, Susan J. T.
    Jansen, Lucres M. C.
    AGGRESSIVE BEHAVIOR, 2015, 41 (05) : 478 - 487
  • [22] The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women
    Gonzalez, Andrea
    Jenkins, Jennifer M.
    Steiner, Meir
    Fleming, Alison S.
    PSYCHONEUROENDOCRINOLOGY, 2009, 34 (01) : 76 - 86
  • [23] Evaluation of salivary cortisol levels in relation to dento-maxillary prosthesis adjustment
    Kosaka, Moe
    Sumita, Yuka I.
    Taniguchi, Hisashi
    Suzuki, Toshihiko
    Sasaki, Keiichi
    JOURNAL OF PROSTHODONTIC RESEARCH, 2019, 63 (01) : 73 - 77
  • [24] ANXIETY, INHIBITION, AND CONDUCT DISORDER IN CHILDREN .2. RELATION TO SALIVARY CORTISOL
    MCBURNETT, K
    LAHEY, BB
    FRICK, PJ
    RISCH, C
    LOEBER, R
    HART, EL
    CHRIST, MAG
    HANSON, KS
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1991, 30 (02): : 192 - 196
  • [25] The determination of salivary cortisol
    Zylberman, Marcelo
    Arcondo, Florencia
    Odzak, Andrea
    MEDICINA-BUENOS AIRES, 2014, 74 (04) : 351 - 351
  • [26] Salivary cortisol or cortisone?
    Hershel Raff
    James W. Findling
    Nature Reviews Endocrinology, 2010, 6 : 658 - 660
  • [27] Clock genes, ADHD and aggression
    Mogavero, Floriana
    Jager, Amanda
    Glennon, Jeffrey C.
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 91 : 51 - 68
  • [28] Predicting aggression in children with ADHD
    Elif Ercan
    Eyüp Sabri Ercan
    Hakan Atılgan
    Bürge Kabukçu Başay
    Taciser Uysal
    Sevim Berrin İnci
    Ülkü Akyol Ardıç
    Child and Adolescent Psychiatry and Mental Health, 8
  • [29] Predicting aggression in children with ADHD
    Ercan, Elif
    Ercan, Eyup Sabri
    Atilgan, Hakan
    Basay, Burge Kabukcu
    Uysal, Taciser
    Inci, Sevim Berrin
    Ardic, Ulku Akyol
    CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH, 2014, 8
  • [30] Comparative analysis of salivary cortisol measurements using different assay methods in relation to serum-free cortisol measurement
    Lee, Anna
    Jang, Sooah
    Lee, Sanghoo
    Park, Hyun-Kyung
    Kim, In -Young
    Ahn, Ryunsup
    Seok, Jeong-Ho
    Lee, Kyoung-Ryul
    PRACTICAL LABORATORY MEDICINE, 2024, 40