Antiviral drug discovery: preparing for the next pandemic

被引：131

作者：

Adamson, Catherine S. ^{[1
]}

Chibale, Kelly ^{[2
,3
,4
]}

Goss, Rebecca J. M. ^{[5
]}

Jaspars, Marcel ^{[6
]}

Newman, David J. ^{[7
]}

Dorrington, Rosemary A. ^{[8
]}

机构：

[1] Univ St Andrews, Sch Biol, Biomed Sci Res Complex, St Andrews KY16 9ST, Fife, Scotland

[2] Univ Cape Town, Drug Discovery & Dev Ctr H3D, ZA-7701 Rondebosch, South Africa

[3] Univ Cape Town, South African Med Res Council, Drug Discovery & Dev Res Unit, Dept Chem, ZA-7701 Rondebosch, South Africa

[4] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa

[5] Univ St Andrews, Sch Chem, St Andrews, Fife, Scotland

[6] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Old Aberdeen AB24 3DT, Scotland

[7] NCI, Nat Prod Branch, Frederick Natl Lab, NIH, Bethesda, MD 20892 USA

[8] Rhodes Univ, Dept Biochem & Microbiol, Grahamstown, South Africa

来源：

CHEMICAL SOCIETY REVIEWS | 2021年 / 50卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

SARS; GS-5734;

D O I：

10.1039/d0cs01118e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.

引用

页码：3647 / 3655

页数：9

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