Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

被引：23
|
作者：
Tokunaga, Y [1 ]
Takenaka, K [1 ]
Asayama, R [1 ]
Shibuya, T [1 ]
机构：
[1] HAMANOMACHI GEN HOSP,DEPT INTERNAL MED,CHUO KU,FUKUOKA 810,JAPAN
来源：
INTERNAL MEDICINE | 1996年 / 35卷 / 06期
关键词：
systemic lupus erythematosus; interstitial pneumonitis; cytomegalovirus;
D O I：
10.2169/internalmedicine.35.517
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide, Fine crackles were audible in the lower lungs bilaterally, Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood, Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.
引用
收藏
页码：517 / 520
页数：4
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