Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women

被引：63

作者：

Obruca, Andreas ^{[1
]}

Tews, Gernot ^{[3
]}

Mardesic, Tonko ^{[4
]}

Mrazek, Milan ^{[5
]}

Meinertz, Helle ^{[6
]}

Hedon, Bernard ^{[7
]}

Barriere, Paul ^{[8
]}

Kim, ChungHoon ^{[9
]}

Koong, Mikyoung ^{[10
]}

Yoon, TaeKi ^{[11
]}

Koziol, Katarzyna ^{[12
]}

Kuczynski, Waldemar ^{[13
]}

Bernabeu, Rafael ^{[14
]}

Ruiz Balda, Jose Antonio ^{[15
]}

Bergh, Christina ^{[16
]}

Hillensjo, Torbjorn ^{[17
]}

Huang, Hong-Yuan ^{[18
]}

Yang, Yu-Shih ^{[19
]}

von Mauw, Ellemiek ^{[20
]}

Elbers, Jolanda ^{[20
]}

Witjes, Han ^{[20
]}

Zandvliet, Anthe S. ^{[20
]}

Mannaerts, Bernadette ^{[20
]}

Schenk, Michael ^{[2
]}

机构：

[1] Kinderwunschzentrum Privatspital Goldenes Kreuz, Vienna, Austria

[2] Kinderwunsch Inst Schenk GmbH, Dobl, Austria

[3] Landes Frauen Und Kinderklin Linz, Linz, Austria

[4] Sanatorium PRONATAL, Prague, Czech Republic

[5] ISCARE IVF AS, Prague, Czech Republic

[6] Hvidovre Univ Hosp, Fertil Clin, Hvidovre, Denmark

[7] Hop Arnaud De Villeneuve, Montpellier, France

[8] Hop De La Mere & De Lenfant, Nantes, France

[9] Asan Med Ctr, Seoul, South Korea

[10] Kwandong Univ, Cheil Gen Hosp, Seoul, South Korea

[11] CHA Gen Hosp, Seoul, South Korea

[12] Przychodnia Lekarska Novum, Warsaw, Poland

[13] Centrum Leczenia Nieplodnosci Malzenskiej Kr, Bialystok, Poland

[14] Inst Bernabeu, Alicante, Spain

[15] Hosp Univ 12 Octubre, Madrid, Spain

[16] Sahlgrenska Universitetssjukhuset, Kvinnoklin, Gothenburg, Sweden

[17] Fertilitetscentrum Carlanderska Sjukhuset, Gothenburg, Sweden

[18] Chang Gung Mem Hosp Linkou, Tao Yuan, Taiwan

[19] Natl Taiwan Univ Hosp, Taipei, Taiwan

[20] Womens Hlth & Endocrine, MSD, Global Clin Res, NL-5340 BH Oss, Netherlands

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2010年 / 21卷 / 01期

关键词：

body weight; corifollitropin alfa; follicle stimulant; IVF; ovarian stimulation; sustained; IN-VITRO FERTILIZATION; FSH-CTP; RECOMBINANT FSH; LIVE BIRTH; HORMONE; AGONIST; ANTAGONISTS;

D O I：

10.1016/j.rbmo.2010.03.019

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In this double-blind, double-dummy, randomized, equivalence trial (Ensure), 396 women weighing 60 kg or less who underwent controlled ovarian stimulation prior to IVF or intracytoplasmic sperm injection were randomized in a 2:1 ratio to a single dose of 100 mu g corifollitropin alfa or daily 150 IU recombinant FSH (rFSH) for the first 7 days of stimulation in a gonadotrophin-releasing hormone antagonist protocol. The mean +/-SD number of oocytes retrieved per started cycle was 13.3 +/- 7.3 for corifollitropin alfa versus 10.6 +/- 5.9 for rFSH. The estimated treatment difference of +2.5 oocytes (95% CI 1.2-3.9) in favour of corifollitropin alfa (P < 0.001) was well within the predefined equivalence margin. The median (range) duration of stimulation was 9 (6-15) days in both groups. In 32.8% of the patients, one injection of corifollitropin alfa was sufficient to reach the human chorionic gonadotrophin criterion. The incidence of moderate and severe ovarian hyperstimulation syndrome was 3.4% for corifollitropin alfa and 1.6% for rFSH. A dose of 100 mu g corifollitropin alfa offers a simplified treatment option for potential normal responder patients with a lower body weight. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：66 / 76

页数：11

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