Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

被引：5

作者：

Zhang, Kong ^{[1
]}

Li, Tianze ^{[1
]}

Shan, Xijie ^{[1
]}

Lu, Rongfei ^{[1
]}

Zhang, Shaoyong ^{[2
]}

Xu, Hui ^{[1
,2
]}

机构：

[1] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China

[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Zhejiang, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2021年 / 21卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Cholesterol derivatives; biological activities; structural modification; mechanisms of action; structure-activity relationships; LIQUID-CRYSTALS SYNTHESIS; HIGH-DENSITY-LIPOPROTEIN; MEMBRANE CHOLESTEROL; LIPID RAFTS; BIOLOGICAL-MEMBRANES; CELLULAR CHOLESTEROL; OXYSTEROLS; PROTEIN; HOMEOSTASIS; DERIVATIVES;

D O I：

10.2174/1389557521666210105123320

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac ac-tivity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structure-activity relationships of cholesterol and its related derivatives are also discussed.

引用

页码：1830 / 1848

页数：19

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