Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms

被引：246
|
作者：
Zhou, Zhao-Li [2 ]
Yang, Ya-Xi [1 ]
Ding, Jian [2 ]
Li, Yuan-Chao [1 ]
Miao, Ze-Hong [2 ]
机构：
[1] Chinese Acad Sci, Dept Med Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
来源：
NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 04期
基金：
中国国家自然科学基金;
关键词：
WILFORDII HOOK-F; NF-KAPPA-B; CELL-CYCLE ARREST; TRIPTERYGIUM-WILFORDII; (5R)-5-HYDROXYTRIPTOLIDE LLDT-8; CANCER CELLS; RHEUMATOID-ARTHRITIS; GENE-EXPRESSION; IN-VITRO; MATRIX-METALLOPROTEINASE;
D O I：
10.1039/c2np00088a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
引用
收藏
页码：457 / 475
页数：19
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