Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions

被引：16
|
作者：
Joseph, Devaneyan [1 ]
Park, Myeong Seong [1 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 28期
基金：
新加坡国家研究基金会;
关键词：
H BOND-CLEAVAGE; N-C CLEAVAGE; SECONDARY AMIDES; CARBOXAMIDES; ACTIVATION;
D O I：
10.1039/d1ob00967b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.
引用
收藏
页码：6227 / 6232
页数：6
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