Elevated urine neopterin levels in nonalcoholic steatohepatitis

被引：14
|
作者：
Yaman, H
Cakir, E [1 ]
Ozcan, O
Yesilova, Z
Ozcan, A
Akgul, EO
Erbil, MK
Bagci, S
Bilgi, C
Dagalp, K
机构：
[1] Gulhane Mil Med Acad, Dept Emergency Med, TR-06010 Ankara, Turkey
[2] Gulhane Mil Med Acad, Dept Biochem & Clin Biochem, TR-06010 Ankara, Turkey
[3] Gulhane Mil Med Acad, Dept Gastroenterol, TR-06010 Ankara, Turkey
[4] Gulhane Mil Med Acad, Dept Pathol, Ankara, Turkey
来源：
CLINICAL BIOCHEMISTRY | 2005年 / 38卷 / 02期
关键词：
urine neopterin; nonalcoholic steatohepatitis; grading; staging;
D O I：
10.1016/j.clinbiochem.2004.10.008
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: The aim of this study was to relate urine levels of neopterin, a marker of activation of the cellular immune system, with grading and staging of NASH. Design and methods: Urine concentrations of neopterin, routine tests, insulin and C-peptide levels were assessed in 50 patients with NASH, 25 patients with chronic viral hepatitis (CVH), and in 26 healthy controls. Results: Urine neopterin levels were found elevated in the NASH and CVH groups compared with controls. There was no significant correlation between urine neopterin levels and inflammation grade in the liver. Conclusions: Urine neopterin levels are a marker of cellular immunity and are higher in patients with NASH. However, neopterin levels were not significantly associated with histopathological grade and stage of disease. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.
引用
收藏
页码：187 / 190
页数：4
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