High-resolution light microscopy using luminescent nanoparticles

被引：37

作者：

Ohulchanskyy, Tymish Y. ^{[1
]}

Roy, Indrajit ^{[1
]}

Yong, Ken-Tye ^{[1
]}

Pudavar, Haridas E. ^{[1
,2
]}

Prasad, Paras N. ^{[1
]}

机构：

[1] SUNY Buffalo, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA

[2] Leica Microsyst, Div Life Sci, Exton, PA USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2010年 / 2卷 / 02期

关键词：

MODIFIED SILICA NANOPARTICLES; CDSE QUANTUM DOTS; AGGREGATION-ENHANCED FLUORESCENCE; UP-CONVERSION EMISSIONS; NAYF4; NANOCRYSTALS; PANCREATIC-CANCER; GOLD NANORODS; IN-VITRO; MULTIPHOTON MICROSCOPY; 2-PHOTON ABSORPTION;

D O I：

10.1002/wnan.67

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This review presents recent progress in the development of the luminescent nanoparticles for confocal and multiphoton microscopy. Four classes of nanomaterials are discussed: (1) silica-based nanoparticles doped with fluorescent molecules, (2) gold nanoparticles, (3) semiconductor nanocrystals (quantum dots/rods), and (4) nanophosphors. Special considerations are given to recently developed imaging nanoprobes, such as (1) organically modified silica (ORMOSIL) nanoparticles doped with two-photon absorbing fluorophores, which exhibit aggregation-enhanced fluorescence (AEF), and (2) nanophosphors (ceramic nanoparticles containing luminescent lanthanoid ions). Advantages and disadvantages of every class of nanomaterials and their specific applications are briefly discussed. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2010 2 162-175

引用

页码：162 / 175

页数：14

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