Nonchromatographic Isolation of 2-Alkyl-2H-1,2,3-Triazoles in the Synthesis of NK3 Receptor Antagonists

被引：1

作者：

Wang, Huan ^{[1
]}

Yin, Hao ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Chem Dev, King Of Prussia, PA 19406 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 02期

关键词：

AZIDE-ALKYNE CYCLOADDITION; TERMINAL ALKYNES; OXIDATION;

D O I：

10.1021/op900320j

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A nonchromatographic isolation of a 2-alkyl-2H-triazole from a 1:1 mixture with the corresponding 1-alkyl-1H isomer was developed in a scalable synthesis of a synthetic intermediate for NK3 receptor antagonists. Based on the fundamental nucleophilicity difference in die isomeric triazoles, this method could he used as a general tactic in the isolation of 2H-triazoles.

引用

页码：474 / 476

页数：3

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