ANCA-associated vasculitides: advances in pathophysiology and treatment

被引:0
|
作者
Erwig, L-P. [1 ]
Savage, C. O. S. [2 ]
机构
[1] Univ Aberdeen, Inst Med Sci, Sch Med, Aberdeen AB9 1FX, Scotland
[2] Univ Birmingham, Coll Med & Dent Sci, Birmingham, W Midlands, England
来源
NETHERLANDS JOURNAL OF MEDICINE | 2010年 / 68卷 / 02期
关键词
ANCA; vasculitis; autoimmune disease; Wegeners granulomatosis; microscopic polyangiitis; Churg Strauss vasculitis; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; ANTIBODY-ASSOCIATED VASCULITIS; REFRACTORY WEGENERS-GRANULOMATOSIS; ENDOTHELIAL CELL-INTERACTIONS; RANDOMIZED-TRIAL; IMMUNOSUPPRESSIVE THERAPY; SYSTEMIC VASCULITIS; GLOMERULONEPHRITIS; DISEASE; CYCLOPHOSPHAMIDE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Substantial progress has been made over the last two decades in our understanding of the immunopathogenesis of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. Compelling evidence from in vitro studies and experimental models in conjunction with clinical trials has confirmed that ANCA directly contribute to the evolution and progression of the disease process. Continuous development in our understanding of the mechanisms that drive the disease may ultimately allow us to tailor the multitude of novel therapies, which are rapidly becoming available, to the requirements of individual patients. In this review we endeavour to provide a brief overview of the recent advances in ANCA-associated vasculitides and outline basic principles for diagnosis and treatment of these complex multisystem diseases.
引用
收藏
页码:62 / 67
页数:6
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