Expression and Sequence of CYP1A1 in the Camel

被引：12

作者：

Darwish, Wageh Sobhy ^{[1
,2
]}

Morshdy, Alaa Eldin ^{[2
]}

Ikenaka, Yoshinori ^{[1
]}

Ibrahim, Zein Shaban ^{[1
,3
]}

Fujita, Shoichi ^{[1
]}

Ishizuka, Mayumi ^{[1
]}

机构：

[1] Hokkaido Univ, Toxicol Lab, Dept Environm Vet Sci, Grad Sch Vet Med,Kita Ku, Sapporo, Hokkaido 0600818, Japan

[2] Zagazig Univ, Dept Food Hyg, Fac Vet Med, Zagazig 44519, Egypt

[3] Kafr El Sheikh Univ, Dept Biochem & Physiol, Fac Vet Med, Kafr Al Sheikh 54363, Egypt

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2010年 / 72卷 / 02期

关键词：

camel; CYP1A; cytochrome P450; lung; tongue; TISSUE-SPECIFIC EXPRESSION; CYTOCHROME-P450; EXPRESSION; EXTRAHEPATIC TISSUES; MESSENGER-RNA; LIVER; RAT; INDUCTION; TONGUE; GENES; P450;

D O I：

10.1292/jvms.09-0319

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In this study, we determined a partial sequence of CYPIA1 in the camel and its phylogenetic position. The deduced amino acid sequence of camel CYPIA1 showed the highest identity 94% with those of sheep and cattle CYPIA1. In a phylogenetic analysis, the camel CYPIA1 isoform was located beside sheep and cattle CYPIA1. When we studied the distribution of camel CYPIA1 mRNA in different tissues, we found that this isoform was expressed in all tissues except the hump. Interestingly, the lungs of all the camels and tongues of two of the three animals showed high expressions of CYPIA1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.

引用

下载

页码：221 / 224

页数：4

共 50 条

[41] A potential role for nuclear α-actinin 4 in regulating CYP1A1 expression
Poch, MT
Smolinski, SM
Hines, RN
FASEB JOURNAL, 2002, 16 (04): : A180 - A180
[42] Biochemical characterization of variants of canine CYP1A1 using heterologous expression
Yu, Hee Jeong
Lee, Seung Heon
Lee, Seungwoo
Choi, Yu Jung
Oh, Dayoung
Nam, Ki-Hoan
Yun, YoungMin
Ryu, Doug-Young
JOURNAL OF VETERINARY MEDICAL SCIENCE, 2017, 79 (08): : 1327 - 1334
[43] Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker
Chessa, M. A.
La Placa, M.
Patrizi, A.
Virdi, A.
Misciali, C.
Fedrizzi, G.
Filippi, F.
Saurat, J. -H.
Sorg, O.
Fontao, F.
Kaya, G.
Neri, I.
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2021, 46 (05) : 896 - 900
[44] In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
Suter, Melissa
Abramovici, Adi
Showalter, Lori
Hu, Min
Do Shope, Cynthia
Varner, Michael
Aagaard-Tillery, Kjersti
METABOLISM-CLINICAL AND EXPERIMENTAL, 2010, 59 (10): : 1481 - 1490
[45] Transient expression of CYP1A1 in rat epithelial cells cultured in suspension
Monk, SA
Denison, MS
Rice, RH
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2001, 393 (01) : 154 - 162
[46] Comparative induction of CYP1A1 expression by pyridine and pyridine metabolites.
Iba, MM
Fung, J
Thomas, PE
Okey, AB
FASEB JOURNAL, 1999, 13 (05): : A813 - A813
[47] CHARACTERIZATION OF HAMSTER CYP1A1 GENE - INDUCIBLE EXPRESSION AND NEGATIVE REGULATION
SAGAMI, I
KIKUCHI, H
IKAWA, S
WATANABE, M
JOURNAL OF BIOCHEMISTRY, 1994, 116 (04): : 801 - 810
[48] Role of CYP1A1 MspI polymorphism in CYP1A1 gene with susceptibility to lung cancer in Iranian patients
Motovali-Bashi, Majid
Biglari, Mostafa
Hojati, Zohreh
Hemati, Simin
Khodadad, Kian
JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2012, 17 : S243 - S247
[49] CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor
Anttila, S
Tuominen, P
Hirvonen, A
Nurminen, M
Karjalainen, A
Hankinson, O
Elovaara, E
PHARMACOGENETICS, 2001, 11 (06): : 501 - 509
[50] Variation in induced CYP1A1 levels:: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
Smart, J
Daly, AK
PHARMACOGENETICS, 2000, 10 (01): : 11 - 24

← 1 2 3 4 5 →