Expression and Sequence of CYP1A1 in the Camel

被引：12

作者：

Darwish, Wageh Sobhy ^{[1
,2
]}

Morshdy, Alaa Eldin ^{[2
]}

Ikenaka, Yoshinori ^{[1
]}

Ibrahim, Zein Shaban ^{[1
,3
]}

Fujita, Shoichi ^{[1
]}

Ishizuka, Mayumi ^{[1
]}

机构：

[1] Hokkaido Univ, Toxicol Lab, Dept Environm Vet Sci, Grad Sch Vet Med,Kita Ku, Sapporo, Hokkaido 0600818, Japan

[2] Zagazig Univ, Dept Food Hyg, Fac Vet Med, Zagazig 44519, Egypt

[3] Kafr El Sheikh Univ, Dept Biochem & Physiol, Fac Vet Med, Kafr Al Sheikh 54363, Egypt

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2010年 / 72卷 / 02期

关键词：

camel; CYP1A; cytochrome P450; lung; tongue; TISSUE-SPECIFIC EXPRESSION; CYTOCHROME-P450; EXPRESSION; EXTRAHEPATIC TISSUES; MESSENGER-RNA; LIVER; RAT; INDUCTION; TONGUE; GENES; P450;

D O I：

10.1292/jvms.09-0319

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In this study, we determined a partial sequence of CYPIA1 in the camel and its phylogenetic position. The deduced amino acid sequence of camel CYPIA1 showed the highest identity 94% with those of sheep and cattle CYPIA1. In a phylogenetic analysis, the camel CYPIA1 isoform was located beside sheep and cattle CYPIA1. When we studied the distribution of camel CYPIA1 mRNA in different tissues, we found that this isoform was expressed in all tissues except the hump. Interestingly, the lungs of all the camels and tongues of two of the three animals showed high expressions of CYPIA1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.

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页码：221 / 224

页数：4

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