A new antibiotic, antimycin A9, produced by Streptomyces sp K01-0031

被引：53
|
作者：
Shiomi, K
Hatae, K
Hatano, H
Matsumoto, A
Takahashi, Y
Jiang, CL
Tomoda, H
Kobayashi, S
Tanaka, H
Omura, S
机构：
[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan
[2] Kitasato Inst, Minato Ku, Tokyo 1088641, Japan
[3] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan
[4] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan
[5] Yunnan Univ, Yunnan InstMicrobiol, Kunming 650091, Yunnan, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 01期
基金：
日本学术振兴会;
关键词：
antimycin; nematocidal; insecticidal; antibiotic;
D O I：
10.1038/ja.2005.10
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new antimycin group antibiotic, antimycin A(9), was isolated from a cultured broth of Streptomyces sp. K01-0031 together with antimycins A(3a), A(3b), A(4), and A(7), and flazin methyl ester. Antimycin A(9) is the first antimycin having an aromatic 8-acyl residue. It showed potent nematocidal and insecticidal activities against Caenorhabditis elegans and Artemia salina, respectively. It inhibited bovine heart NADH oxidase at nanomolar level like other known antimycins.
引用
收藏
页码：74 / 78
页数：5
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