A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

被引：0

作者：

Awano, Yuta ^{[1
]}

Ishii, Ryoya ^{[2
]}

Takahashi, Yume ^{[1
]}

Tsutsumi, Hayama ^{[1
,3
]}

Watanabe, Yoshihiro ^{[1
,3
]}

Sonoda, Masaaki ^{[1
]}

Hokari, Rei ^{[1
,3
]}

Iwatsuki, Masato ^{[1
,3
]}

Inahashi, Yuki ^{[1
,3
]}

机构：

[1] Kitasato Univ, Grad Sch Infect Control Sci, 5-9-1 Shirokane,Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Sch Sci, 1-15-1 Kitazato,Minami Ku, Sagamihara, Kanagawa 2520373, Japan

[3] Kitasato Univ, Omura Satoshi Mem Inst, 5-9-1 Shirokane,Minato Ku, Tokyo 1088641, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2024年 / 77卷 / 08期

关键词：

ENDOPHYTIC ACTINOMYCETE; YS-822A;

D O I：

10.1038/s41429-024-00737-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.

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页码：540 / 543

页数：4

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