Response and resistance to PD-1 pathway blockade: clues from the tumor microenvironment

被引：0
|
作者：
Ascierto, Maria Libera [1 ,2 ]
McMiller, Tracee L. [2 ,3 ]
Berger, Alan E. [2 ,4 ]
Danilova, Ludmila [1 ,2 ]
Anders, Robert A. [2 ,5 ]
Netto, George J. [2 ,5 ]
Xu, Haiying [2 ,7 ]
Pritchard, Theresa S. [2 ,3 ]
Fan, Jinshui [2 ,4 ]
Cheadle, Chris [2 ,4 ]
Cope, Leslie [1 ,2 ]
Drake, Charles G. [1 ,2 ,6 ]
Pardoll, Drew M. [1 ,2 ]
Taube, Janis M. [2 ,5 ,7 ]
Topalian, Suzanne L. [2 ,3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21287 USA
[2] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Sch Med, Lowe Family Genom Core, Baltimore, MD 21287 USA
[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA
[6] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA
[7] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD USA
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2016年 / 14卷
关键词：
CANCER;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
K20
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma
    Li, Sen
    Zhao, Chenyang
    Gao, Jinlan
    Zhuang, Xinbin
    Liu, Shuang
    Xing, Xuesha
    Liu, Qi
    Chen, Chen
    Wang, Shusen
    Luo, Yang
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021, 40 (01)
  • [42] Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade
    Xue Li
    Manni Wang
    Rong Xiang
    Signal Transduction and Targeted Therapy, 4
  • [43] Inhibitors of the PD-1 Pathway in Tumor Therapy
    LaFleur, Martin W.
    Muroyama, Yuki
    Drake, Charles G.
    Sharpe, Arlene H.
    JOURNAL OF IMMUNOLOGY, 2018, 200 (02): : 375 - 383
  • [44] An In Silico Glioblastoma Microenvironment Model Dissects the Immunological Mechanisms of Resistance to PD-1 Checkpoint Blockade Immunotherapy
    Zhang, Zhuoyu
    Liu, Lunan
    Ma, Chao
    Cui, Xin
    Lam, Raymond H. W.
    Chen, Weiqiang
    SMALL METHODS, 2021, 5 (06)
  • [45] RADIOFREQUENCY ABLATION PLUS PD-1 BLOCKADE SHAPES THE ANTITUMOR MICROENVIRONMENT
    Li, Shuang
    Zeng, Xuezhen
    Song, Tongtong
    Zhao, Xiao
    Peng, Sui
    Kuang, Ming
    Mei, Jie
    GASTROENTEROLOGY, 2024, 166 (05) : S1718 - S1718
  • [46] An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer
    Voabil, Paula
    de Bruijn, Marjolein
    Roelofsen, Lisanne M.
    Hendriks, Sanne H.
    Brokamp, Simone
    van den Braber, Marlous
    Broeks, Annegien
    Sanders, Joyce
    Herzig, Petra
    Zippelius, Alfred
    Blank, Christian U.
    Hartemink, Koen J.
    Monkhorst, Kim
    Haanen, John B. A. G.
    Schumacher, Ton N.
    Thommen, Daniela S.
    NATURE MEDICINE, 2021, 27 (07) : 1250 - +
  • [47] Tumor organoid-originated biomarkers predict immune response to PD-1 blockade
    Bozkus, Cansu Cimen
    Bhardwaj, Nina
    CANCER CELL, 2021, 39 (09) : 1187 - 1189
  • [48] Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer
    Akinori Sasaki
    Yoshiaki Nakamura
    Yosuke Togashi
    Hirofumi Kuno
    Hidehiro Hojo
    Shunichiro Kageyama
    Naoki Nakamura
    Kenji Takashima
    Tomohiro Kadota
    Yusuke Yoda
    Saori Mishima
    Kentaro Sawada
    Daisuke Kotani
    Akihito Kawazoe
    Yasutoshi Kuboki
    Hiroya Taniguchi
    Takashi Kojima
    Toshihiko Doi
    Takayuki Yoshino
    Tomonori Yano
    Tatsushi Kobayashi
    Tetsuo Akimoto
    Hiroyoshi Nishikawa
    Kohei Shitara
    Gastric Cancer, 2020, 23 : 893 - 903
  • [49] Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer
    Sasaki, Akinori
    Nakamura, Yoshiaki
    Togashi, Yosuke
    Kuno, Hirofumi
    Hojo, Hidehiro
    Kageyama, Shunichiro
    Nakamura, Naoki
    Takashima, Kenji
    Kadota, Tomohiro
    Yoda, Yusuke
    Mishima, Saori
    Sawada, Kentaro
    Kotani, Daisuke
    Kawazoe, Akihito
    Kuboki, Yasutoshi
    Taniguchi, Hiroya
    Kojima, Takashi
    Doi, Toshihiko
    Yoshino, Takayuki
    Yano, Tomonori
    Kobayashi, Tatsushi
    Akimoto, Tetsuo
    Nishikawa, Hiroyoshi
    Shitara, Kohei
    GASTRIC CANCER, 2020, 23 (05) : 893 - 903
  • [50] Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
    de Erauso, Luisa Chocarro
    Zuazo, Miren
    Arasanz, Hugo
    Bocanegra, Ana
    Hernandez, Carlos
    Fernandez, Gonzalo
    Garcia-Granda, Maria Jesus
    Blanco, Ester
    Vera, Ruth
    Kochan, Grazyna
    Escors, David
    FRONTIERS IN PHARMACOLOGY, 2020, 11
12345