Helicobacter pylori virulence factors and the host immune response:: implications for therapeutic vaccination

被引：56
|
作者：
Prinz, C [1 ]
Hafsi, N [1 ]
Voland, P [1 ]
机构：
[1] Tech Univ Munich, Dept Med 2, D-81675 Munich, Germany
来源：
TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 03期
关键词：
D O I：
10.1016/S0966-842X(03)00024-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Helicobacter pylori colonizes the human gastric mucosa and is associated with specific gastric disease. Virulence factors, such as urease, the vacuolating toxin (VacA), the cytotoxin-associated antigen CagA or blood-group-antigen-binding adhesin (BabA), an adherence factor, might account for the development of different diseases. Vaccination trials exploiting the antigenic properties of some of these proteins have not been successful in preventing infection in humans. A more in-depth understanding of the immune response to H. pylori infection as well as additional information on suitable epitopes and adjuvants will be required before a successful vaccine can be developed.
引用
收藏
页码：134 / 138
页数：5
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