Synthesis of a technetium-99m-labeled thymidine analog: a potential HSV1-TK substrate for non-invasive reporter gene expression imaging

被引：16
|
作者：
Zhang, Y
Dai, XM
Kallmes, DF
Pan, DF [1 ]
机构：
[1] Univ Virginia, Dept Radiol, Charlottesville, VA 22908 USA
[2] Mayo Clin, Dept Radiol, Rochester, MN 55902 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 47期
关键词：
FTcAU; TK substrate; nuclear imaging; reporter probe;
D O I：
10.1016/j.tetlet.2004.09.145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
{2-[5-(2'-Fluoro-2'-deoxyuridin-5-yl)pent-4(E)-enyl] [2-(2-mercaptoethyl)aminoethyl]aminoethanethiolato(3)-N,N' ,S,S'}-oxo[Tc-99m]technetium(V), a potential viral thymidine kinase substrate, was synthesized by coupling 2-fluoro-2'-deoxyuridine analog with a N2S2 radiometal chelator, followed by [Tc-99m]technetilim conjugation. The chemical structure of the radioactive probe was characterized by H-1 NMR and high resolution MS using Re-188 conjugated mimics. The radiochemical purity and yield were identified as 98% and 42%, respectively. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：8673 / 8676
页数：4
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