Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells

被引：31

作者：

Chiu, Sheng-Chun ^{[1
]}

Huang, Sung-Ying ^{[2
]}

Chang, Shu-Fang ^{[1
]}

Chen, Shee-Ping ^{[3
]}

Chen, Chi-Cheng ^{[4
,5
]}

Lin, Tien-Huang ^{[4
,5
]}

Liu, Hsin-Ho ^{[4
,5
]}

Tsai, Tsung-Hsun ^{[4
,5
]}

Lee, Shang-Sen ^{[4
,5
]}

Pang, Cheng-Yoong ^{[6
,7
]}

Hsieh, Teng-Fu ^{[4
,5
]}

机构：

[1] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Res, Taichung 427, Taiwan

[2] Mackay Mem Hosp, Dept Ophthalmol, Hsinchu 30071, Taiwan

[3] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Tzu Chi Stem Cells Ctr, Hualien 970, Taiwan

[4] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Urol, Taichung 427, Taiwan

[5] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan

[6] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med Res, Hualien 970, Taiwan

[7] Tzu Chi Univ, Sch Med, Inst Med Sci, Hualien 970, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期

关键词：

Tanshinone IIA; bladder cancer; metastasis; cisplatin; combination therapy; HUMAN BREAST-CANCER; GROWTH-INHIBITION; HEPATOCELLULAR-CARCINOMA; IN-VITRO; MOLECULAR-MECHANISMS; APOPTOSIS INDUCTION; PROTEIN EXPRESSION; CASPASE; 12; CISPLATIN; METASTASIS;

D O I：

10.3390/ijms150915622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase-and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time-and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer.

引用

页码：15622 / 15637

页数：16

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